Thursday, February 25, 2010

THANKS TO ALL MY DOCTORS- NOW I'M BECOME MORE BETTER

Hospital Universiti Sains Malaysia Kubang Kerian Surgeon :

             1. Dr. Siew Baw
             2. Dr. Khaznizal
             3. Dr. Lim
             4. Dr. Faizul
             5. Pakar Bius(Doctor from Indonesia)

ACCIDENTAL AND EMERGENCY 
         ALL DOCTORS AND STAFFNURSE
            

Ward 2 Intan Doctor and Staff
             1. Dr.Mehbob Alam Pasya
             2. Dr. Izani
             3. Dr. Ikhwan
             4. Dr. Mohamad from Afrika
             5. Dr. Salwani
             6.Dr.Zuhdi
             7. Dr. Liew
             8. Others doctor was treat me


Ward 1 Selatan

            All doctor and staffnurse especially staffnurse Zabidah that is my neighbour.

 Nuclear and Oncology Clinic

             1. Prof.Madya Dr.Biswa Mohan Biswal
             2. Prof.Madya Dr.Hasanah Che Ismail
             3. Dr.Wan Yus Hanif
             4. Dr.Wan Fatihah Wan Mohd Suhaimi
             5. Others doctor that i dont know their name.
     Also Staffnurses and Members of Lab.

Clinic OGDS:
            Doctors and staffnurse

Radiiology Clinic
           All doctors and staffnurse make Barrium enigma, CT Scan and FISTULAGRAM

HOSPITAL RAJA PEREMPUAN ZAINAB II

          1. MR. OTHMAN - SURGEON SPECIALIST
          2. ALL DOCTORS THAT TREAT ME
          3..ALL STAFFNURSE AT SURGERY CLINIC AND PALLIATIVE WARD


  HOSPITAL BESAR PULAU PINANG


         1. ALL SPECIALIST, DOCTOR , STAFFNURSE THAT MAKE PET-SCAN 


MAY ALLAH (MY GOD) BLESS YOU ALL. THANKS FOR EVERYTHINGS. I'M NEVER FORGET YOURS  KINDNESS.



MUHAMAD ZAINI ISMAIL
CANCER GIST SURVIVOR


         

Wednesday, February 24, 2010

RADIOTERAPI UNTUK PESAKIT KANSER

Radiation therapy

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Radiation therapy of the pelvis. Lasers and a mould under the legs are used to determine exact position.

Varian Clinac 2100C Linear Accelerator.
Radiation therapy (in North America), or radiotherapy (in the UK and Australia) also called radiation oncology, and sometimes abbreviated to XRT, is the medical use of ionizing radiation as part of cancer treatment to control malignant cells (not to be confused with radiology, the use of radiation in medical imaging and diagnosis). Radiotherapy may be used for curative or adjuvant cancer treatment. It is used as palliative treatment (where cure is not possible and the aim is for local disease control or symptomatic relief) or as therapeutic treatment (where the therapy has survival benefit and it can be curative). Total body irradiation (TBI) is a radiotherapy technique used to prepare the body to receive a bone marrow transplant. Radiotherapy has several applications in non-malignant conditions, such as the treatment of trigeminal neuralgia, severe thyroid eye disease, pterygium, pigmented villonodular synovitis, prevention of keloid scar growth, and prevention of heterotopic ossification. The use of radiotherapy in non-malignant conditions is limited partly by worries about the risk of radiation-induced cancers.
Radiotherapy is used for the treatment of malignant tumors (cancer), and may be used as the primary therapy. It is also common to combine radiotherapy with surgery, chemotherapy, hormone therapy or some mixture of the three. Most common cancer types can be treated with radiotherapy in some way. The precise treatment intent (curative, adjuvant, neoadjuvant, therapeutic, or palliative) will depend on the tumour type, location, and stage, as well as the general health of the patient.
Radiation therapy is commonly applied to the cancerous tumour. The radiation fields may also include the draining lymph nodes if they are clinically or radiologically involved with tumour, or if there is thought to be a risk of subclinical malignant spread. It is necessary to include a margin of normal tissue around the tumour to allow for uncertainties in daily set-up and internal tumor motion. These uncertainties can be caused by internal movement (for example, respiration and bladder filling) and movement of external skin marks relative to the tumour position.
To spare normal tissues (such as skin or organs which radiation must pass through in order to treat the tumour), shaped radiation beams are aimed from several angles of exposure to intersect at the tumour, providing a much larger absorbed dose there than in the surrounding, healthy tissue.

Contents

[hide]

[edit] Mechanism of action

Radiation therapy works by damaging the DNA of cells. The damage is caused by a photon, electron, proton, neutron, or ion beam directly or indirectly ionizing the atoms which make up the DNA chain. Indirect ionization happens as a result of the ionization of water, forming free radicals, notably hydroxyl radicals, which then damage the DNA. In the most common forms of radiation therapy, most of the radiation effect is through free radicals. Because cells have mechanisms for repairing DNA damage, breaking the DNA on both strands proves to be the most significant technique in modifying cell characteristics. Because cancer cells generally are undifferentiated and stem cell-like, they reproduce more, and have a diminished ability to repair sub-lethal damage compared to most healthy differentiated cells. The DNA damage is inherited through cell division, accumulating damage to the cancer cells, causing them to die or reproduce more slowly.
One of the major limitations of radiotherapy is that the cells of solid tumors become deficient in oxygen. Solid tumors can outgrow their blood supply, causing a low-oxygen state known as hypoxia. Oxygen is a potent radiosensitizer, increasing the effectiveness of a given dose of radiation by forming DNA-damaging free radicals. Tumor cells in a hypoxic environment may be as much as 2 to 3 times more resistant to radiation damage than those in a normal oxygen environment.[1] Much research has been devoted to overcoming this problem including the use of high pressure oxygen tanks, blood substitutes that carry increased oxygen, hypoxic cell radiosensitizers such as misonidazole and metronidazole, and hypoxic cytotoxins, such as tirapazamine. There is also interest in the fact that high-LET (linear energy transfer) particles such as carbon or neon ions may have an antitumor effect which is less dependent of tumor oxygen because these particles act mostly via direct damage.

[edit] Dose

The amount of radiation used in radiation therapy is measured in gray (Gy), and varies depending on the type and stage of cancer being treated. For curative cases, the typical dose for a solid epithelial tumor ranges from 60 to 80 Gy, while lymphoma tumors are treated with 20 to 40 Gy.
Preventative (adjuvant) doses are typically around 45 - 60 Gy in 1.8 - 2 Gy fractions (for Breast, Head and Neck cancers respectively.) Many other factors are considered by radiation oncologists when selecting a dose, including whether the patient is receiving chemotherapy, whether radiation therapy is being administered before or after surgery, and the degree of success of surgery.
Delivery parameters of a prescribed dose are determined during treatment planning (part of dosimetry). Treatment planning is generally performed on dedicated computers using specialized treatment planning software. Depending on the radiation delivery method, several angles or sources may be used to sum to the total necessary dose. The planner will try to design a plan that delivers a uniform prescription dose to the tumor and minimizes dose to surrounding healthy tissues.

[edit] Fractionation

The total dose is fractionated (spread out over time) for several important reasons. Fractionation allows normal cells time to recover, while tumor cells are generally less efficient in repair between fractions. Fractionation also allows tumor cells that were in a relatively radio-resistant phase of the cell cycle during one treatment to cycle into a sensitive phase of the cycle before the next fraction is given. Similarly, tumor cells that were chronically or acutely hypoxic (and therefore more radioresistant) may reoxygenate between fractions, improving the tumor cell kill. Fractionation regimes are individualised between different radiotherapy centres and even between individual doctors. In North America, Australia, and Europe, the typical fractionation schedule for adults is 1.8 to 2 Gy per day, five days a week. In the northern United Kingdom, fractions are more commonly 2.67 to 2.75 Gy per day, which eases the burden on thinly spread resources in the National Health Service. In some cancer types, prolongation of the fraction schedule over too long can allow for the tumor to begin repopulating, and for these tumor types, including head-and-neck and cervical squamous cell cancers, radiation treatment is preferably completed within a certain amount of time. For children, a typical fraction size may be 1.5 to 1.8 Gy per day, as smaller fraction sizes are associated with reduced incidence and severity of late-onset side effects in normal tissues.
In some cases, two fractions per day are used near the end of a course of treatment. This schedule, known as a concomitant boost regimen or hyperfractionation, is used on tumors that regenerate more quickly when they are smaller. In particular, tumors in the head-and-neck demonstrate this behavior.
One of the best-known alternative fractionation schedules is Continuous Hyperfractionated Accelerated Radiotherapy (CHART). CHART, used to treat lung cancer, consists of three smaller fractions per day. Although reasonably successful, CHART can be a strain on radiation therapy departments.
Implants can be fractionated over minutes or hours, or they can be permanent seeds which slowly deliver radiation until they become inactive.

[edit] Effect on different types of cancer

Different cancers respond differently to radiation therapy.[2][3][4]
The response of a cancer to radiation is described by its radiosensitivity. Highly radiosensitive cancer cells are rapidly killed by modest doses of radiation. These include leukaemias, most lymphomas and germ cell tumours. The majority of epithelial cancers are only moderately radiosensitive, and require a significantly higher dose of radiation (60-70Gy) to achieve a radical cure. Some types of cancer are notably radioresistant, that is, much higher doses are required to produce a radical cure than may be safe in clinical practice. Renal cell cancer and melanoma are generally considered to be radioresistant.
It is important to distinguish the radiosensitivity of a particular tumour, which to some extent is a laboratory measure, from the radiation "curability" of a cancer in actual clinical practice. For example, leukaemias are not generally curable with radiotherapy, because they are disseminated though the body. Lymphoma may be radically curable if it is localised to one area of the body. Similarly, many of the common, moderately radioresponsive tumours are routinely treated with curative doses of radiotherapy if they are at an early stage. For example: non-melanoma skin cancer, head and neck cancer, non-small cell lung cancer, cervical cancer, anal cancer, prostate cancer. Metastatic cancers are generally incurable with radiotherapy because it is not possible to treat the whole body.
Before treatment, a CT scan is often performed to identify the tumor and surrounding normal structures. The patient is then sent for a simulation so that molds can be created to be used during treatment. The patient receives small skin marks to guide the placement of treatment fields.[5]
The response of a tumour to radiotherapy is also related to its size. For complex reasons, very large tumours respond less well to radiation than smaller tumours or microscopic disease. Various strategies are used to overcome this effect. The most common technique is surgical resection prior to radiotherapy. This is most commonly seen in the treatment of breast cancer with wide local excision or mastectomy followed by adjuvant radiotherapy. Another method is to shrink the tumour with neoadjuvant chemotherapy prior to radical radiotherapy. A third technique is to enhance the radiosensitivity of the cancer by giving certain drugs during a course of radiotherapy. Examples of radiosensiting drugs include: Cisplatin, Nimorazole, and Cetuximab.

[edit] History of radiation therapy

Radiation therapy has been in use as a cancer treatment for more than 100 years, with its earliest roots traced from the discovery of x-rays in 1895 by Wilhelm Röntgen.[6]
The field of radiation therapy began to grow in the early 1900s largely due to the groundbreaking work of Nobel Prize-winning scientist Marie Curie, who discovered the radioactive elements polonium and radium. This began a new era in medical treatment and research.[6] Radium was used in various forms until the mid-1900s when cobalt and caesium units came into use. Medical linear accelerators have been used to as sources of radiation since the late 1940s.
With Godfrey Hounsfield’s invention of computed tomography (CT) in 1971, three-dimensional planning became a possibility and created a shift from 2-D to 3-D radiation delivery; CT-based planning allows physicians to more accurately determine the dose distribution using axial tomographic images of the patient's anatomy. Orthovoltage and cobalt units have largely been replaced by megavoltage linear accelerators, useful for their penetrating energies and lack of physical radiation source.
The advent of new imaging technologies, including magnetic resonance imaging (MRI) in the 1970s and positron emission tomography (PET) in the 1980s, has moved radiation therapy from 3-D conformal to intensity-modulated radiation therapy (IMRT) and image-guided radiation therapy (IGRT). These advances have resulted in better treatment outcomes and fewer side effects.

[edit] Types of radiation therapy

Historically, the three main divisions of radiotherapy are external beam radiotherapy (EBRT or XBRT) or teletherapy, brachytherapy or sealed source radiotherapy, and systemic radioisotope therapy or unsealed source radiotherapy. The differences relate to the position of the radiation source; external is outside the body, brachytherapy uses sealed radioactive sources placed precisely in the area under treatment, and systemic radioisotopes are given by infusion or oral ingestion. Brachytherapy can use temporary or permanent placement of radioactive sources. The temporary sources are usually placed by a technique called afterloading. In afterloading a hollow tube or applicator is placed surgically in the organ to be treated, and the sources are loaded into the applicator after the applicator is implanted. This minimizes radiation exposure to health care personnel. Particle therapy is a special case of external beam radiotherapy where the particles are protons or heavier ions. Introperative radiotherapy[7] is a special type of radiotherapy that is delivered immediately after surgical removal of the cancer. This method has been employed in breast cancer (TARGeted Introperative radioTherapy), brain tumours and rectal cancers.

[edit] External beam radiotherapy

The following three sections refer to treatment using x-rays.

[edit] Conventional external beam radiotherapy

Conventional external beam radiotherapy (2DXRT) is delivered via two-dimensional beams using linear accelerator machines. 2DXRT mainly consists of a single beam of radiation delivered to the patient from several directions: often front or back, and both sides. Conventional refers to the way the treatment is planned or simulated on a specially calibrated diagnostic x-ray machine known as a simulator because it recreates the linear accelerator actions (or sometimes by eye), and to the usually well-established arrangements of the radiation beams to achieve a desired plan. The aim of simulation is to accurately target or localize the volume which is to be treated. This technique is well established and is generally quick and reliable. The worry is that some high-dose treatments may be limited by the radiation toxicity capacity of healthy tissues which lay close to the target tumor volume. An example of this problem is seen in radiation of the prostate gland, where the sensitivity of the adjacent rectum limited the dose which could be safely prescribed using 2DXRT planning to such an extent that tumor control may not be easily achievable. Prior to the invention of the CT, physicians and physicists had limited knowledge about the true radiation dosage delivered to both cancerous and healthy tissue. For this reason, 3-dimensional conformal radiotherapy is becoming the standard treatment for a number of tumor sites.

[edit] Stereotactic Radiation

Stereotactic radiation is a specialized type of external beam radiation therapy. It uses focused radiation beams targeting a well-defined tumor using extremely detailed imaging scans. Radiation oncologists perform stereotactic treatments, often with the help of a neurosurgeon for tumors in the brain or spine.
There are two types of stereotactic radiation. Stereotactic radiosurgery (SRS) is when doctors use a single or several stereotactic radiation treatments of the brain or spine. Stereotactic body radiation therapy (SBRT) refers to one or several stereotactic radiation treatments with the body, such as the lungs[8].
Some doctors say an advantage to stereotactic treatments are they deliver the right amount of radiation to the cancer in a shorter amount of time than traditional treatments, which can often take six to 11 weeks. Plus treatments are given with extreme accuracy, which should limit the effect of the radiation on healthy tissues. One problem with stereotactic treatments is that they are only suitable for certain small tumors.
Stereotactic treatments can be confusing because many hospitals call the treatments by the name of the manufacturer rather than calling it SRS or SBRT. Brand names for these treatments include Axesse, Cyberknife, Gamma Knife, Novalis, Primatom, Synergy, X-Knife, TomoTherapy and Trilogy.[9] This list changes as equipment manufacturers continue to develop new, specialized technologies to treat cancers.

[edit] Virtual simulation, 3-dimensional conformal radiotherapy, and intensity-modulated radiotherapy

The planning of radiotherapy treatment has been revolutionized by the ability to delineate tumors and adjacent normal structures in three dimensions using specialized CT and/or MRI scanners and planning software.[10]
Virtual simulation, the most basic form of planning, allows more accurate placement of radiation beams than is possible using conventional X-rays, where soft-tissue structures are often difficult to assess and normal tissues difficult to protect.
An enhancement of virtual simulation is 3-Dimensional Conformal Radiotherapy (3DCRT), in which the profile of each radiation beam is shaped to fit the profile of the target from a beam's eye view (BEV) using a multileaf collimator (MLC) and a variable number of beams. When the treatment volume conforms to the shape of the tumour, the relative toxicity of radiation to the surrounding normal tissues is reduced, allowing a higher dose of radiation to be delivered to the tumor than conventional techniques would allow.[5]
Intensity-Modulated Radiation Therapy (IMRT) is an advanced type of high-precision radiation that is the next generation of 3DCRT.[11] IMRT also improves the ability to conform the treatment volume to concave tumor shapes,[5] for example when the tumor is wrapped around a vulnerable structure such as the spinal cord or a major organ or blood vessel.[12] Computer-controlled x-ray accelerators distribute precise radiation doses to malignant tumors or specific areas within the tumor. The pattern of radiation delivery is determined using highly-tailored computing applications to perform optimization and treatment simulation (Treatment Planning). The radiation dose is consistent with the 3-D shape of the tumor by controlling, or modulating, the radiation beam’s intensity. The radiation dose intensity is elevated near the gross tumor volume while radiation among the neighboring normal tissue is decreased or avoided completely. The customized radiation dose is intended to maximize tumor dose while simultaneously protecting the surrounding normal tissue. This may result in better tumor targeting, lessened side effects, and improved treatment outcomes than even 3DCRT.
3DCRT is still used extensively for many body sites but the use of IMRT is growing in more complicated body sites such as CNS, head and neck, prostate, breast and lung. Unfortunately, IMRT is limited by its need for additional time from experienced medical personnel. This is because physicians must manually delineate the tumors one CT image at a time through the entire disease site which can take much longer than 3DCRT preparation. Then, medical physicists and dosimetrists must be engaged to create a viable treatment plan. Also, the IMRT technology has only been used commercially since the late 1990s even at the most advanced cancer centers, so radiation oncologists who did not learn it as part of their residency program must find additional sources of education before implementing IMRT.
Proof of improved survival benefit from either of these two techniques over conventional radiotherapy (2DXRT) is growing for many tumor sites, but the ability to reduce toxicity is generally accepted. Both techniques enable dose escalation, potentially increasing usefulness. There has been some concern, particularly with 3DCRT, about increased exposure of normal tissue to radiation and the consequent potential for secondary malignancy. Overconfidence in the accuracy of imaging may increase the chance of missing lesions that are invisible on the planning scans (and therefore not included in the treatment plan) or that move between or during a treatment (for example, due to respiration or inadequate patient immobilization). New techniques are being developed to better control this uncertainty—for example, real-time imaging combined with real-time adjustment of the therapeutic beams. This new technology is called image-guided radiation therapy (IGRT) or four-dimensional radiotherapy.

[edit] Particle Therapy

In particle therapy (Proton therapy), energetic ionizing particles (protons or carbon ions) are directed at the target tumor.[13] The dose increases while the particle penetrates the tissue, up to a maximum (the Bragg peak) that occurs near the end of the particle's range, and it then drops to (almost) zero. The advantage of this energy deposition profile is that less energy is deposited into the healthy tissue surrounding the target tissue.

[edit] Radioisotope Therapy (RIT)

Systemic radioisotope therapy is a form of targeted therapy. Targeting can be due to the chemical properties of the isotope such as radioiodine which is specifically absorbed by the thyroid gland a thousand-fold better than other bodily organs. Targeting can also be achieved by attaching the radioisotope to another molecule or antibody to guide it to the target tissue. The radioisotopes are delivered through infusion (into the bloodstream) or ingestion. Examples are the infusion of metaiodobenzylguanidine (MIBG) to treat neuroblastoma, of oral iodine-131 to treat thyroid cancer or thyrotoxicosis, and of hormone-bound lutetium-177 and yttrium-90 to treat neuroendocrine tumors (peptide receptor radionuclide therapy). Another example is the injection of radioactive glass or resin microspheres into the hepatic artery to radioembolize liver tumors or liver metastases.
A major use of systemic radioisotope therapy is in the treatment of bone metastasis from cancer. The radioisotopes travel selectively to areas of damaged bone, and spare normal undamaged bone. Isotopes commonly used in the treatment of bone metastasis are strontium-89 and samarium (153Sm) lexidronam.[14]
In 2002, the United States Food and Drug Administration (FDA) approved ibritumomab tiuxetan (Zevalin), which is an anti-CD20 monoclonal antibody conjugated to yttrium-90.[15] In 2003, the FDA approved the tositumomab/iodine (131I) tositumomab regimen (Bexxar), which is a combination of an iodine-131 labelled and an unlabelled anti-CD20 monoclonal antibody.[16] These medications were the first agents of what is known as radioimmunotherapy, and they were approved for the treatment of refractory non-Hodgkins lymphoma.

[edit] Side effects

Radiation therapy is in itself painless. Many low-dose palliative treatments (for example, radiotherapy to bony metastases) cause minimal or no side effects, although short-term pain flare up can be experienced in the days following treatment due to oedema compressing nerves in the treated area. Treatment to higher doses causes varying side effects during treatment (acute side effects), in the months or years following treatment (long-term side effects), or after re-treatment (cumulative side effects). The nature, severity, and longevity of side effects depends on the organs that receive the radiation, the treatment itself (type of radiation, dose, fractionation, concurrent chemotherapy), and the patient.
Most side effects are predictable and expected. Side effects from radiation are usually limited to the area of the patient's body that is under treatment. One of the aims of modern radiotherapy is to reduce side effects to a minimum, and to help the patient to understand and to deal with those side effects which are unavoidable.
The main side effects reported are fatigue and skin irritation, like a mild to moderate sun burn. The fatigue often sets in during the middle of a course of treatment and can last for weeks after treatment ends. The skin irritation will also go away, but it may not be as elastic as it was before. Patients should ask their radiation oncologist or radiation oncology nurse about possible products and medications that can help with side effects. [17]

[edit] Acute side effects

Damage to the epithelial surfaces. Epithelial surfaces may sustain damage from radiation therapy. Depending on the area being treated, this may include the skin, oral mucosa, pharyngeal, bowel mucosa and ureter. The rates of onset of damage and recovery from it depend upon the turnover rate of epithelial cells. Typically the skin starts to become pink and sore several weeks into treatment. The reaction may become more severe during the treatment and for up to about one week following the end of radiotherapy, and the skin may break down. Although this moist desquamation is uncomfortable, recovery is usually quick. Skin reactions tend to be worse in areas where there are natural folds in the skin, such as underneath the female breast, behind the ear, and in the groin.
If the head and neck area is treated, temporary soreness and ulceration commonly occur in the mouth and throat.[18] If severe, this can affect swallowing, and the patient may need painkillers and nutritional support/food supplements. The esophagus can also become sore if it is treated directly, or if, as commonly occurs, it receives a dose of collateral radiation during treatment of lung cancer.
The lower bowel may be treated directly with radiation (treatment of rectal or anal cancer) or be exposed by radiotherapy to other pelvic structures (prostate, bladder, female genital tract). Typical symptoms are soreness, diarrhoea, and nausea.
Swelling (edema or oedema). As part of the general inflammation that occurs, swelling of soft tissues may cause problems during radiotherapy. This is a concern during treatment of brain tumours and brain metastases, especially where there is pre-existing raised intracranial pressure or where the tumour is causing near-total obstruction of a lumen (e.g., trachea or main bronchus). Surgical intervention may be considered prior to treatment with radiation. If surgery is deemed unnecessary or inappropriate, the patient may receive steroids during radiotherapy to reduce swelling.
Infertility. The gonads (ovaries and testicles) are very sensitive to radiation. They may be unable to produce gametes following direct exposure to most normal treatment doses of radiation. Treatment planning for all body sites is designed to minimize, if not completely exclude dose to the gonads if they are not the primary area of treatment.

[edit] Late side effects

Late side effects occur months to years after treatment. They are often due to damage of blood vessels and connective tissue cells. Many late effects are reduced by fractionating treatment into smaller parts.
Fibrosis
Tissues which have been irradiated tend to become less elastic over time due to a diffuse scarring process.
Epilation (Hair Loss)
Epilation may occur on any hair bearing skin with doses above 1 Gy. It only occurs within the radiation field/s. Hair loss may be permanent with a single dose of 10 Gy, but if the dose is fractionated permanent hair loss may not occur until dose exceeds 45 Gy.
Dryness
The salivary glands and tear glands have a radiation tolerance of about 30 Gy in 2 Gy fractions, a dose which is exceeded by most radical head and neck cancer treatments. Dry mouth (xerostomia) and dry eyes (xerophthalmia) can become irritating long-term problems and severely reduce the patient's quality of life. Similarly, sweat glands in treated skin (such as the armpit) tend to stop working, and the naturally moist vaginal mucosa is often dry following pelvic irradiation.
Cancer
Radiation is a potential cause of cancer, and secondary malignancies are seen in a very small minority of patients - usually less than 1/1000. It usually occurs 20 - 30 years following treatment, although some haematological malignancies may develop within 5 - 10 years. In the vast majority of cases, this risk is greatly outweighed by the reduction in risk conferred by treating the primary cancer. The cancer occurs within the treated area of the patient.
Heart disease
Radiation has potentially excess risk of death from heart disease seen after some past breast cancer RT regimens.[19]
Cognitive decline
In cases of radiation applied to the head radiation therapy may cause cognitive decline

[edit] Cumulative side effects

Cumulative effects from this process should not be confused with long-term effects—when short-term effects have disappeared and long-term effects are subclinical, reirradiation can still be problematic.[20]

[edit] See also

[edit] References

  1. ^ Harrison LB, Chadha M, Hill RJ, Hu K, Shasha D (2002). "Impact of tumor hypoxia and anemia on radiation therapy outcomes". Oncologist 7 (6): 492–508. doi:10.1634/theoncologist.7-6-492. PMID 12490737. http://theoncologist.alphamedpress.org/cgi/pmidlookup?view=long&pmid=12490737. 
  2. ^ CK Bomford, IH Kunkler, J Walter. Walter and Miller’s Textbook of Radiotherapy (6th Ed), p311
  3. ^ “Radiosensitivity” on GP notebook http://www.gpnotebook.co.uk/simplepage.cfm?ID=2060451853
  4. ^ “Radiotherapy- what GPs need to know” on patient.co.uk http://www.patient.co.uk/showdoc/40002299/
  5. ^ a b c Camphausen KA, Lawrence RC. "Principles of Radiation Therapy" in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer Management: A Multidisciplinary Approach. 11 ed. 2008.
  6. ^ a b "University of Alabama at Birmingham Comprehensive Cancer Center, History of Radiation Oncology" (from the Wayback Machine). http://web.archive.org/web/20080105043216/http://www3.ccc.uab.edu/show.asp?durki=68504. 
  7. ^ Vaidya J. "TARGIT (TARGeted Intraoperative radioTherapy)". http://www.targit.org.uk. Retrieved 2009-09-27. 
  8. ^ http://www.astro.org/PressRoom/PressKit/AnnualMeeting/documents/Timmerman.pdf
  9. ^ http://www.rtanswers.com/treatmentinformation/treatmenttypes/stereotacticradiation.aspx
  10. ^ Bucci M, Bevan A, Roach M (2005). "Advances in radiation therapy: conventional to 3D, to IMRT, to 4D, and beyond.". CA Cancer J Clin 55 (2): 117–34. doi:10.3322/canjclin.55.2.117. PMID 15761080. http://caonline.amcancersoc.org/cgi/content/full/55/2/117. 
  11. ^ Galvin JM, Ezzell G, Eisbrauch A, et al. (Apr 2004). "Implementing IMRT in clinical practice: a joint document of the American Society for Therapeutic Radiology and Oncology and the American Association of Physicists in Medicine". Int J Radiat Oncol Biol Phys. 58 (5): 1616–34. doi:10.1016/j.ijrobp.2003.12.008. PMID 15050343. 
  12. ^ Intensity Modulated Radiation Therapy
  13. ^ Brain tumour patient 'unaware' treatment was available on NHS
  14. ^ Sartor O (2004). "Overview of samarium sm 153 lexidronam in the treatment of painful metastatic bone disease". Rev Urol 6 Suppl 10: S3–S12. PMID 16985930. 
  15. ^ Fda Approves First Radiopharmaceutical Product To Treat Non-Hodgkin’S Lymphoma
  16. ^ Tositumomab and Iodine I 131 Tositumomab - Product Approval Information - Licensing Action
  17. ^ http://www.rtanswers.com/treatmentinformation/cancertypes/breast/possiblesideeffects.aspx
  18. ^ Hall, Eric J. (2000). Radiobiology for the radiologist. Philadelphia: Lippincott Williams Wilkins. p. 351. ISBN 0781726492, 9780781726498. 
  19. ^ Taylor CW, Nisbet A, McGale P, Darby SC (Dec 2007). "Cardiac exposures in breast cancer radiotherapy: 1950s-1990s". Int J Radiat Oncol Biol Phys. 69 (5): 1484–95. doi:10.1016/j.ijrobp.2007.05.034. PMID 18035211. 
  20. ^ Nieder C, Milas L, Ang KK (2000). "Tissue tolerance to reirradiation.". Semin Radiat Oncol 10 (3): 200–9. doi:10.1053/srao.2000.6593. PMID 11034631.

BREAST CANCER ( KANSER PAYUDARA)

Kanser Payudara


1) Epidemiologi:
Kanser payudara adalah kanser yang paling biasa berlaku di antara kaum wanita, bukan sahaja di Amerika Syarikat (210 000 kes setahun), malah di semua negara membangun. Antara kejadian : antara 8-9 orang wanita, seorang daripadanya akan menghidap kanser payudara, ia bergantung kepada negara mana. Kejadian ini terus meningkat 1 hingga 2% setiap tahun, tetapi tahap kematian makin stabil pada sepuluh tahun yang lepas. Kanser Payudara masih sebagai penderitaan masyarakat di negara barat : terutamanya di Amerika Syarikat , Kanada, Eropah Barat, Australia , New Zealand. Pada masa ini, lebih dari 1 juta wanita di Amerika Syarikat menghidap kanser payudara peringkat II, III atau IV. Walaupun sains perubatan belum dapat membanteras kanser ini, kemajuan dalam diagnosis dan terapi dapat merawat ramai pesakit.
Namun demikian, risiko bukan di luar tafsiran sebab ia terlalu kerap: risiko sebenar ialah 13%, dan peninjauan baru-baru ini menunjukkan bahawa 89% kaum wanita di luar tafsiran bagi kanser ini : purata tafsiran 46% dari 13% yang sebenar. Jangan bimbang !
Jangan lupa sebanyak 1000 orang lelaki dipengaruhi setiap tahun di Amerika Syarikat.

2) Faktor Risiko:
Bahkan apa yang menyebabkan kanser payudara tidak diketahui dengan tepat, kanser ini pada umumnya diakui adalah akibat dari perubahan genetik, kebanyakan didapati selepas lahir. Kadang-kadang ia diwarisi dari salah seorang ibubapa : dikenali sebagai predisposisi genetik kepada kanser payudara.

Sehingga sekarang, 2 predisposisi genetik telah dikenalpasti. (lain-lain seperti BRCA3, sedang diselidik): BRCA1 dan BRCA2, yang perlu ditentukan di dalam kes kanser di dalam keluarga.

Faktor risiko yang utama:
- jantina: 100 wanita, 1 lelaki;
- umur: 50 tahun ke atas
- kelainan yang ditemui melalui biopsi payudara
- Akilbaligh awal dan lambat putus haid;
- tidak pernah mengandung atau lewat mengandung.
Penyebab lain yang disahkan tetapi dengan kadar risiko rendah: - persekitaran (cara hidup, kedudukan sosial, makanan), - kegemukan semasa muda, - rawatan hormon, - tembakau, - alkohol.
3) Perkembangan:
Sel mamari di payudara membesar dan menebus limfa atau saluran darah menyebabkan metastasis. Tumor ini dapat dikesan melalui mamografi, ultrasound, MRI dan nodus aksilari. Jikalau tumor itu tidak dirawat, ia akan membesar dan metastasis akan membawa maut.
4) Simptom:
ketulan di payudara, kemungkinan menyebabkan kulit berhampiran berkedut, kelainan pada puting, puting berdarah, nodus aksilari.
5) Pengesanan kanser payudara:
Cara paling baik untuk rawatan lengkap.
- pemeriksaan sendiri payudara.
- mamografi bilateral, sekali setiap tahun atau setiap 2 tahun selepas umur 40 (atau umur 50, terpulang kepada
negara mana). Kemungkinan untuk mengesan tumor pada peringkat awal sebelum ia tersebar.
- ultrasound dinasihatkan.
- Petanda tumor diperlukan.
bergantung kepada
- mamografi;
- ultrasound; MRI ;
- biopsi: samada core-biopsi (fine-needle aspiration), atau biopsi pembedahan.
- dan petanda tumor : CEA , CA 15-3.

SUSU LEBAH(ROYAL JELLY) PENAWAR CANCER

SUSU LEBAH PENAWAR KANSER








"Bengkak atau pembesaran sel abnormal yang terletak dalam tisu atau organ badan dikenali sebagai tumor." Tumor malignan atau kanser mempunyai kebolehan untuk menyerang sel normal dan merebak ke seluruh badan." Oleh itu Malignan tumor malignan boleh menjejas kehidupan kita. Sebaliknya tumor benigna tidak akan menyerang tisu sebelah dan tidak merebak ke seluruh badan. Oleh itu tumor benigna tidak menjejaskan kehidupan manusia. Walau bagaimanapun sesetengah



sel dalam tumor benigna boleh berubah dan menjadi malignan dan berkanser. Tumor boleh menjadi benigna atau malignan , dan beberapa tumor benigna boleh berubah dengan peredaran masa untuk menjadi tumor malignan atau kanser.



Susu Lebah adalah makanan anak anak lebah setelah ia dilahirkan selama tiga hari. Tetapi susu lebah ini menjadi makanan ratu lebah sehingga akhir hayatnya. Ratu lebah tidak mencari madu seperti lebah pekerja. Tugas ratu lebah hanyalah bertelur sahaja. Ia akan bertelur sepanjang hayatnya.

Terdapat satu bahan didalam susu lebah yang tidak terdapat didalam benda lain ialah 10-HDA. 10-HDA telah diuji secara klinikal memang terbukti dapat membantut prtumbuhan sel sel tumor dan kanser.



Sebagaimana yang disebut di dalam Al Quran ~ Sesungguhnya cecair yang keluar dari perut lebah adalah penawar segala penyakit~. Semoga kita semua mendapat manafaat daripada kejadian Allah Subha Nahuwatala.







Susu Lebah

Penawar Mujarab Untuk Penyakit Kanser

Posted by jibam on Saturday 09 January 2010 - 01:06:24
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SUSU LEBAH PENAWAR KANSER








"Bengkak atau pembesaran sel abnormal yang terletak dalam tisu atau organ badan dikenali sebagai tumor." Tumor malignan atau kanser mempunyai kebolehan untuk menyerang sel normal dan merebak ke seluruh badan." Oleh itu Malignan tumor malignan boleh menjejas kehidupan kita. Sebaliknya tumor benigna tidak akan menyerang tisu sebelah dan tidak merebak ke seluruh badan. Oleh itu tumor benigna tidak menjejaskan kehidupan manusia. Walau bagaimanapun sesetengah



sel dalam tumor benigna boleh berubah dan menjadi malignan dan berkanser. Tumor boleh menjadi benigna atau malignan , dan beberapa tumor benigna boleh berubah dengan peredaran masa untuk menjadi tumor malignan atau kanser.



Susu Lebah adalah makanan anak anak lebah setelah ia dilahirkan selama tiga hari. Tetapi susu lebah ini menjadi makanan ratu lebah sehingga akhir hayatnya. Ratu lebah tidak mencari madu seperti lebah pekerja. Tugas ratu lebah hanyalah bertelur sahaja. Ia akan bertelur sepanjang hayatnya.

Terdapat satu bahan didalam susu lebah yang tidak terdapat didalam benda lain ialah 10-HDA. 10-HDA telah diuji secara klinikal memang terbukti dapat membantut prtumbuhan sel sel tumor dan kanser.



Sebagaimana yang disebut di dalam Al Quran ~ Sesungguhnya cecair yang keluar dari perut lebah adalah penawar segala penyakit~. Semoga kita semua mendapat manafaat daripada kejadian Allah Subha Nahuwatala.







Susu Lebah

Penawar Mujarab Untuk Penyakit Kanser

Posted by jibam on Saturday 09 January 2010 - 01:06:24
Comments are turned off for this item







Saturday, February 13, 2010

KANSER PARU-PARU(LUNG CANCER)


Kanser Paru-paru


Di seluruh dunia, kanser paru-paru merupakan kanser paling umum dan boleh membawa maut.

Adakah anda tahu :
- kanser paru-paru adalah pembunuh nombor satu antara kematian kanser yang berlaku ?
- sebanyak 157 000 kematian di Amerika Syarikat pada tahun 2003 adalah disebabkan oleh kanser paru-paru ?
- merokok secara pasif mungkin mempercepatkan pertumbuhan kanser ?
- 87% dari pesakit kanser paru-paru merokok, tetapi 13% daripada pesakit tidak merokok ?
- hanya 1 daripada 9 orang yang merokok akan menghidap kanser paru-paru, bukan 8 orang yang lain itu : adakah anda salah seorang daripada mereka yang bernasib baik ? Angka ini didapati dari persatuan kanser yang paling penting, iaitu ACS dan NCI (American Cancer Society dan National Cancer Institute). Biomarkers ? Informasi yang penting tentang kanser paru-paru dan merokok : perokok yang kuat lebih mungkin menghidap penyakit ini. Namun demikian,
-tiada kajian yang menunjukkan perokok cerut (<5 cigars/wk, bukan menarik nafas) meningkatkan kejadian kanser paru-paru.
-bukan sentiasa merokok (<1 pk/wk) tidak pernah menunjukkan ia adalah satu faktor risiko dalam kanser paru-paru.
- setengah pencemaran lebih bahaya daripada asap dari perokok.

Untuk membuat penjelasan, jalankan pemeriksaan yang teliti, seperti Ujian Biomarkers C12 dinasihatkan. Lakukannya, nyawa anda di dalam taruhan.
1) Epidemiologi:
Kanser paru-paru adalah "pembunuh nombor satu": kanser yang bersebar luas di seluruh dunia. Ia masih meningkat. Namun demikian, tidak dapat dinafikan kemajuan telah dicapai tahun kebelakangan ini sejauh mana rawatan berkenaan. Kanser ini disebabkan oleh penggunaan tobako, ia bermula di negara barat sejak perang dunia kedua. Ia mewakili 20% dari kesemua kanser di Amerika Utara, dibanding 1 ke 2% di Afrika. Sila perhatikan bahawa penyakit ini berlaku agak umum di kalangan wanita, sebab tabiat merokok mereka. : Kanser paru-paru menjadi masalah yang semakin besar pada wanita setiap tahun. Jika kecenderungan sekarang berlanjutan, dalam masa 10 ke 15 tahun, kes kanser paru-paru pada lelaki dan wanita akan muncul : kejadian ini akan menjadi sama, bila 3.5:1 (3 kali lebih bagi lelaki) pada tahun 1975, dan 1.5:1 pada tahun 1999.
Umur yang sesuai untuk diagnosa ialah 66 tahun.

Rawatan kanser paru-paru adalah susah, sebab ia sudah terlewat apabila membuat rawatan: bila membuat diagnosa pada peringkat lewat, , 50% daripada kes-kes menunjukkan metastasis.
Semakin ramai kematian yang disebabkan oleh kanser paru-paru dibanding dengan pergabungan kanser kolon, payudara dan prostat.
Dalam tahun 2004, anggaran kes-kes baru kanser paru-paru di Amerika Syarikat adalah 173,770 : 93,110 kes-kes antara lelaki dan 80,660 antara wanita, menurut kepada Persatuan Kanser Amerika.
menaksir 160,400 kematian, lebih kurang 30% daripada semua kematian yang disebabkan oleh kanser, akan berlaku dalam tahun 2004.
2) Faktor risiko:
- Merokok atau pendedahan ke asap rokok. Risiko yang lebih tinggi jikalau menghisap rokok dibanding dengan
menghisap cerut atau paip .
- Pendedahan ke bahan kimia industri : Asbestos adalah satu dari bahan kimia yang diketahui, gas
radon, kadmium, nikel, bahan kimia industri, tar dan habuk karbon.
- Perokok lebih berisiko jika didedahkan ke bahan kimia industri tersebut dan pencemaran atmosfera.
- Fakta genetik pun memainkan peranan kerana hanya seorang dari sepuluh perokok yang menghidap penyakit ini.
3) Perkembangan kanser:
Kanser paru-paru dibahagikan kepada 2 jenis, iaitu “small cells lung cancer” (SCLC), dan “non-small cells lung cancers” (NSCLC) mewakili 25% dan 75% masing-masing. Sel-sel paru-paru menukar menjadi sel-sel kanser apabila berlaku ketidakseimbangan fakta-fakta perkembangan sel tersebut. Barah ini boleh melarat ke tulang, hati dan otak.

4) Simptom:
- Batuk berdarah;
- batuk yang berlarutan;
- jangkitan kuman saluran pernafasan dan paru-paru yang susah diubati;
- Suara kasar, lemah lesu dan susut berat badan;
- Sakit-sakit tulang, air dalam pelura para-paru dan sakit tulang belakang.